Kidney injury molecule‐1 (KIM‐1)‐mediated anti‐inflammatory activity is preserved by Mucin 1 (MUC1) induction in the proximal tubule during ischemia‐reperfusion injury
نویسندگان
چکیده
منابع مشابه
Complement activation and kidney injury molecule-1-associated proximal tubule injury in severe preeclampsia.
Kidney injury with proteinuria is a characteristic feature of preeclampsia, yet the nature of injury in specific regions of the nephron is incompletely understood. Our study aimed to use existing urinary biomarkers to describe the pattern of kidney injury and proteinuria in pregnancies affected by severe preeclampsia. We performed a case-control study of pregnant women from Brigham and Women's ...
متن کاملMuc1 is protective during kidney ischemia-reperfusion injury.
Ischemia-reperfusion injury (IRI) due to hypotension is a common cause of human acute kidney injury (AKI). Hypoxia-inducible transcription factors (HIFs) orchestrate a protective response in renal endothelial and epithelial cells in AKI models. As human mucin 1 (MUC1) is induced by hypoxia and enhances HIF-1 activity in cultured epithelial cells, we asked whether mouse mucin 1 (Muc1) regulates ...
متن کاملProximal tubule - targeted heme oxygenase - 1 in cisplatin - induced acute kidney injury 1 2 3 4
Proximal tubule-targeted heme oxygenase-1 in cisplatin-induced acute kidney injury 1 2 3 4 Subhashini Bolisetty, Amie Traylor, Reny Joseph, Abolfazl Zarjou, Anupam 5 Agarwal 6 7 Department of Medicine, Nephrology Research and Training Center and Department of Cell, 8 Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, 9 Alabama 35294, Birmingham Veterans Admi...
متن کاملProximal tubule-targeted heme oxygenase-1 in cisplatin-induced acute kidney injury.
Heme oxygenase-1 (HO-1) is a cytoprotective enzyme that catalyzes the breakdown of heme to biliverdin, carbon monoxide, and iron. The beneficial effects of HO-1 expression are not merely due to degradation of the pro-oxidant heme but are also credited to the by-products that have potent, protective effects, including antioxidant, anti-inflammatory, and prosurvival properties. This is well refle...
متن کاملActivation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury.
Agonists of the sphingosine-1-phosphate receptor (S1PR) attenuate kidney ischemia-reperfusion injury (IRI). Previous studies suggested that S1P1R-induced lymphopenia mediates this protective effect, but lymphocyte-independent mechanisms could also contribute. Here, we investigated the effects of S1PR agonists on kidney IRI in mice that lack T and B lymphocytes (Rag-1 knockout mice). Administrat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2021
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.2021.35.s1.04311